Cousin volume shipments out of (a) SBP change, (Gaussian fit Roentgen 2 getting salt sensitive and painful = 0.74 and you may sodium resistant = 0.97) and you may (b) urinary Na + /K + , (Gaussian match Roentgen dos getting sodium painful and sensitive = 0.99 and you will sodium resistant someone = 0.99) throughout the gang of sodium delicate (n = 71) and you will salt resistant (letter = 119) people with change of slimming down input out of Dieting Answers to End Hypertension (DASH) higher sodium (HS) eating plan in order to Dash lower sodium (LS) diet plan.

New member demographics

One of analysis users analyzed, 53% out-of SR and you can 62% of SS users have been girls, 51% regarding SR and you will 63% regarding SS professionals had been African-American (Dining table 1). Many users were old 30–55 decades, college-knowledgeable, and https://datingranking.net/craigslist-hookup/ you will functioning full time. There have been no tall variations in baseline services to possess research people round the ethnicity otherwise gender in either the fresh SS otherwise SR communities (Desk step 1).

Baseline SBP, assessed during the screening visit prior to dietary intervention was significantly higher in SS (137.6 ± 8.7 mmHg) vs. SR participants (132.5 ± 9.6 mmHg; p < 0.05, Table 2). In contrast there was no significant difference in 24 h urinary Na + excretion, 24 h urinary K + excretion and the urinary Na + :K + ratio between SS and SR participants at screening (Table 2). Further, there was no significant effect of sex or ethnicity on these variables, as such subsequent analyses were not adjusted for age or ethnicity. In SS, but not SR participants, each additional g/day in urinary Na + excretion across the range of <2 g/day to 5 g/day resulted in a higher SBP value of approximately 1.0 ± 0.4 mmHg in SBP/g Na + excretion (Fig. 2a). The measures >5 g/day Na+ were not included due to increased sample variability. When assessed by linear regression across the entire range of observed Na + excretion we observed no correlation between urinary Na + excretion and SBP in either SS (R 2 = 0.02) or SR (R 2 = 0.02) participants (Fig. 2b). In both SS and SR participants urinary K + excretion of <1 g/day elevated SBP by 3.9 and 4.8 mmHg respectively vs. SBP values obtained for urinary excretion of 1–1.99gK + /day (Fig. 3a) and the Cohen's D score for the difference in the SBP among the participants with less than 1 g/day versus 1-1.9 g/day of urinary K + excretion showed a medium effect size in both SS (0.45) and the SR (0.49) group. However, when assessed across the entire range of observed K + excretion we observed no correlation between K + excretion and SBP in either SS (R 2 = 0.001) or SR (R 2 = 0.008) participants (Fig. 3b). Further, we observed no association between the urinary Na + :K + ratio and SBP and no impact of urinary K + excretion across any dietary Na + excretion range on SBP in either SS (R 2 = 0.004) or SR (R 2 = 0.002) participants (Fig. 4a, b).

Impression off Dash diet towards association regarding urinary salt to potassium removal ratio which have SBP

Within the sub group of SS participants randomly assigned to DASH-Sodium dietary intervention arm (N = 71) there was a significant (p < 0.05) reduction in SBP on the DASH-LS diet compared to the baseline screening SBP value (Table 3). In the sub group of SR participants randomly assigned to the DASH-Sodium intervention (N = 119) there were significant (p < 0.05) reductions in SBP on both the DASH-HS and DASH-LS diets compared to the baseline screening SBP value (Table 3). On the DASH-Sodium diet, following both the LS and HS interventions compared to screening there was a significant (p < 0.05) increase in urinary K + excretion and reduction in the urinary Na + :K + ratio (that was greater during the LS intervention), in both SS and SR participants (Table 3).